I installed an Intel 750 GB PCIe SSD last week, in order to get some of my VM's better disk performance. After running without problems for almost 7 days straight, something happened. All VM's that had their boot-disks on the SSD were inaccessible, and both the ESXI Web UI and the console was slow and practically unusable. Had to make "hard reset". After the reboot everything was back to normal. Same thing happened again after another 2 days. VM's that was running on the RAID-array wasn't affected and was accessible.
The nvme driver is "intel-nvme" version 1.2.1.15-1OEM.650.0.0.4598673.
Before I installed the drive I updated the firmware to the latest available.
Motherboard: Tyan S5510GM3NR, BIOS v2.02
CPU: Xeon E3-1265L v2
If/when it happens again I'll try extract the system logs and see if it give any clues.
Known issue? Possibly a bad drive?